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Efficacy of a new formulation of amphotericin B in a murine model of disseminated infection by Candida glabrata.

Mariné M, Espada R, Torrado J, Pastor FJ, Guarro J

Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain.

OBJECTIVES: Amphotericin B poly-aggregates are a new formulation of amphotericin B, which can be obtained cheaply. In this study, we tested the efficacy of this new formulation for treating a disseminated infection by Candida glabrata in a murine model. METHODS: Mice were rendered neutropenic by intraperitoneal cyclophosphamide and intravenous 5-fluorouracil administration and infected intravenously with 2 x 10(8) cfu of C. glabrata. The efficacy of the new formulation of amphotericin B was evaluated by survival and tissue burden studies. The experiments were repeated using three different clinical strains of C. glabrata. RESULTS AND CONCLUSIONS: Amphotericin B poly-aggregates showed an efficacy similar to that of amphotericin B deoxycholate and liposomal amphotericin B in the treatment of a disseminated murine infection by C. glabrata.

Published 19 March 2008 in J Antimicrob Chemother, 61(4): 880-3.
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