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CaIPF7817 is involved in the regulation of redox homeostasis in Candida albicans.

Jia JH, Wang Y, Cao YB, Gao PH, Jia XM, Ma ZP, Xu YG, Dai BD, Jiang YY

Department of Pharmacology, School of Life Science and Biopharmacology, Shenyang Pharmaceutical University, Shenyang 110016, PR China.

CaIPF7817, a functionally unknown gene in Candida albicans, was suggested to be involved in the redox system previously, but its exact role is unknown. In this study, ipf7817 null mutant was generated with the URA-blaster method. After the deletion of CaIPF7817, intracellular levels of reactive oxygen species were significantly increased; mitochondrial membrane potential, a direct indicator of mitochondrial function, was elevated; some important redox-related genes, including GLR1, SOD2, and TRR1, were up-regulated; and the GSH/GSSG ratio was raised. These changes indicated that CaIPF7817 played important roles in the regulation of redox homeostasis in C. albicans.

Published 5 June 2007 in Biochem Biophys Res Commun, 359(1): 163-7.
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