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Application of microsatellite typing for the investigation of a cluster of cases of Candida albicans candidaemia.

Beretta S, Fulgencio JP, Enache-Angoulvant A, Bernard C, El Metaoua S, Ancelle T, Denis M, Hennequin C

Laboratoire de Parasitologie-Mycologie, Hôpital Cochin, Paris, France.

A cluster of cases of Candida albicans candidaemia in a surgical intensive care unit was investigated. The probability of such a cluster during a single month was highly significant compared with the frequency of candidaemia in the previous year. A molecular typing method, based on length analysis of three (EF3, CDC3, HIS3) microsatellite-containing regions, was used to investigate isolates from patients in and outside the ward. This demonstrated the involvement of different strains, indicating the absence of cross-transmission among patients. Results of microsatellite typing can be obtained almost in real-time, which is particularly useful in an outbreak context.

Published 15 June 2006 in Clin Microbiol Infect, 12(7): 674-6.
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