Candida Research Today is a free monthly online journal that collates and summarizes the latest research about Candida, including details on thrush infections, yeast, diet, treatment, symptoms.

Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.

Onyewu C, Afshari NA, Heitman J

Department of Ophthalmology, Wadsworth Bldg., Box 3802, Erwin Road, Duke University Eye Center, Durham, NC 27710, USA. afsha003@mc.duke.edu

In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.

Published 26 October 2006 in Antimicrob Agents Chemother, 50(11): 3963-5.
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