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In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility.

Cota J, Carden M, Graybill JR, Najvar LK, Burgess DS, Wiederhold NP

University of Texas at Austin College of Pharmacy, UTHSCSA, Clinical Pharmacy, MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC(50) values), and IC(90) values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

Published 26 October 2006 in Antimicrob Agents Chemother, 50(11): 3926-8.
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