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Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.

Mosel DD, Dumitru R, Hornby JM, Atkin AL, Nickerson KW

School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666, USA.

Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

Published 8 August 2005 in Appl Environ Microbiol, 71(8): 4938-40.
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