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Caspofungin susceptibility testing of Candida inconspicua: correlation of different methods with the minimal fungicidal concentration.

Majoros L, Kardos G, Szabó B, Sipiczki M

Department of Medical Microbiology, University of Debrecen, 4032 Debrecen, Nagyerdei krt. 98, Hungary. major@jaguar.dote.hu

Minimal inhibitory and minimal fungicidal concentrations of caspofungin were determined for 48 Candida inconspicua isolates. By using CLSI (formerly NCCLS) methodology with the partial inhibition endpoint criterion, caspofungin exhibited a good fungicidal effect against C. inconspicua (the MIC(90) was 0.25 microg/ml and the minimum fungicidal concentration [MFC] was 0.5 microg/ml after 24 h). Total inhibition yielded falsely elevated MICs, exceeding even the respective MFCs.

Published 28 July 2005 in Antimicrob Agents Chemother, 49(8): 3486-8.
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