Candida Research Today is a free monthly online journal that collates and summarizes the latest research about Candida, including details on thrush infections, yeast, diet, treatment, symptoms.

Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans.

Lo HJ, Wang JS, Lin CY, Chen CG, Hsiao TY, Hsu CT, Su CL, Fann MJ, Ching YT, Yang YL

Division of Clinical Research, National Health Research Institutes, Taipei, Taiwan, Republic of China.

The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.

Published 24 February 2005 in Antimicrob Agents Chemother, 49(3): 1213-5.
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