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Effects of cetylpyridinium chloride resistance and treatment on fluconazole activity versus Candida albicans.

Edlind MP, Smith WL, Edlind TD

Department of Microbiology and Immunology, Drexel University of College of Medicine, 2900 Queen Ln., Philadelphia, PA 19129, USA.

Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.

Published 27 January 2005 in Antimicrob Agents Chemother, 49(2): 843-5.
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