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Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice.

Pultz NJ, Stiefel U, Ghannoum M, Helfand MS, Donskey CJ

Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA.

We examined the effect of antibiotic treatment on establishment of intestinal colonization by Candida glabrata in adult mice. Subcutaneous ceftriaxone, piperacillin-tazobactam, clindamycin, and metronidazole promoted increased density of stool colonization, whereas cefepime, levofloxacin, and aztreonam did not. These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization.

Published 23 December 2004 in Antimicrob Agents Chemother, 49(1): 438-40.
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